Download PDF by Charles M. King (auth.), Lawrence J. Marnett (eds.): Arachidonic Acid Metabolism and Tumor Initiation

By Charles M. King (auth.), Lawrence J. Marnett (eds.)

ISBN-10: 146129634X

ISBN-13: 9781461296348

ISBN-10: 1461326117

ISBN-13: 9781461326113

Show description

Read or Download Arachidonic Acid Metabolism and Tumor Initiation PDF

Similar nonfiction_8 books

Download e-book for kindle: Boundary Elements XIII by R. T. Bailey, C. K. Hsieh (auth.), C. A. Brebbia, G. S.

Because its foundation in 1978, the overseas convention on Boundary aspect tools has supplied the famous and demonstrated discussion board for options in boundary point learn. essentially all new principles on boundary ele­ ments were offered at those meetings and the ensuing papers are available within the released books.

Symmetries and Singularity Structures: Integrability and by P. Winternitz (auth.), Professor Dr. Muthuswamy Lakshmanan, PDF

Those lectures take care of history and most recent advancements in symmetries, singularity constructions (Painlevé research) and their relation to integrability and chaos in classical and quantum nonlinear dynamical structures. The ebook comes in handy to either novices and senior researchers in physics and arithmetic operating within the box of nonlinear dynamics.

Download e-book for kindle: Targeting the Foreign Direct Investor: Strategic Motivation, by Edward J. Coyne Sr. C.D.(Hon.)(Jamaica) B. Sc., M.I.B.A.,

Overseas Direct funding (FDI) is one street for supplying suggestions to constructing international locations of their efforts to develop. Small nations as a rule have constrained assets to direct towards funding allure courses, so the facility to section the marketplace (of Multinational companies trying to make investments) is an important ability.

Orchid Biology: Reviews and Perspectives, VII by Joseph Arditti (auth.), Joseph Arditti, Alec M. Pridgeon PDF

A private observe i made a decision to start up Orchid Biology: stories and views in approximately 1972 and (alone or with co-authors) began to write the various chapters and the appendix for the amount in 1974 in the course of a trip to the Bogor Botanical Gardens in Indonesia. Professor H. C. D. de Wit of Holland used to be additionally in Bogor at the moment and after we chanced on a joint curiosity in Rumphius he agreed to jot down a bankruptcy approximately him.

Additional info for Arachidonic Acid Metabolism and Tumor Initiation

Sample text

Hilbert 0, Romen W, Neumann H-G: The role of partial hepatectomy and promoters in the formation of tumors in non-target tissues of trans-4-acetylaminostilbene in rats. Carcinogenesis (4): 1519-1525, 1983. 51. Mulder GJ, Meerman JHN: Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: The role of N,O-sulfonation in chemical carcinogenesis of aromatic amines. Environmental Health Perspectives (49): 27-32, 1983. 52. Dao TL: Studies on mechanism of carcinogenesis in th~ mammary gland.

ID u ID 0.. •• ::J ...... PG Biosynthesis •• •• • • ••• -. CD 50 Mutovenlclt, 10 Time 15 20 (min) FIGURE 7. Comparison of the time courses of PGH2 biosynthesis, BP-7,S-diol metabolism, and generation of a mutagen from BP-7,S-diol. Further support for epoxidation of BP-7,8-diol to the antidiolepoxide is the identification of RNA and DNA adducts formed as a result of incubation of BP-7,8-diol, PGH synthase, and polyguanylic acid or DNA (57,5S). Following digestion of the nucleic acid, the major guanosine and deoxyguanosine adducts were identified as arising by addition of the exocyclic amino group of guanosine to the benzylic carbon of the anti-diolepoxide (57,58).

Peroxyl radicals are moderately stable 55 eq. 1-10 sec) that are relatively selective oxidizing agents (67). They can abstract hydrogen to form hydroperoxides or insert oxygen into isolated double bonds. We have detected· and identified the hydroperoxide formed during peroxidatic metabolism of phenylbutazone and shown that it is reduced to an alcohol when incubated with microsomal preparations (P. H. Siedlik and L. J. Marnett, unpublished results). This accounts for the overall hydroxylation of phenylbutazone that occurs as a result of its oxidation by PGH synthase.

Download PDF sample

Arachidonic Acid Metabolism and Tumor Initiation by Charles M. King (auth.), Lawrence J. Marnett (eds.)


by Charles
4.4

Rated 4.99 of 5 – based on 50 votes